Combinations ; See Below
1. Lamivudine / Tenofovir
2. Lamivudine / Tenofovir / Efavirenz
3. Lamivudine / Zidovudine
4. Lamivudine / Zidovudine / Abacavir
5. Lamivudine / Zidovudine / Nevirapine
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Epivir | GlaxoSmithkline | GlaxoSmithKline | 150mg | 60 | Tablet | per tablet | KES 1,890.00 |
| Epivir | GlaxoSmithkline | GlaxoSmithKline | 10mg | 240ml | Suspension | per 5ML | KES 2,963.10 |
| Heptavir | Hetero Drugs Ltd | Unisel Pharma (K) Ltd. | 150mg | 60 | Tablet | per tablet | KES 434.00 |
| Lamiriv | Cosmos Limited. | Cosmos Limited | 150mg | 60 | Tablet | per tablet | KES 380.00 |
| Lamivir | Cipla Ltd. | Surgipharm Ltd | 150mg | 60 | Tablet | per tablet | KES 515.00 |
| Lamivir | Cipla Ltd. | Surgipharm Ltd | 10mg | 100ml | Suspension | per 5ML | KES 160.00 |
| Lavir | Emcure Pharmaceuticals Limited | Saicare Enterprises Ltd. | 150mg | 60 | Tablet | per tablet | KES 990.00 |
| Lamivudine (3TC) More info | |
|---|---|
| Mode Of Action | Nucleoside reverse transcriptase inhibitors (NRTIs) that are converted by cellular cells? enzymes to active phosporylated metabolites that inhibit viral reverse transcriptase and viral DNA synthesis. |
| Drug Indication | HIV infection (in combination with other anti-retrovirals); chronic hepatitis B viral infection after evidence of replication (positive PCR test results).BV |
| Precautions | If creatinine clearance is below 50mL/minute reduce the dose and do not use the drug in combination with any other ARVs; to watch out on the possibility of rebound of hepatitis B infection after stopping treatment in case of HIV/ hepatitis B co-infections. In advanced disease, combination with AZT is prone to produce serious anaemia at the begining of treatment hence complete blood count is done initially and repeated at 3-month intervals. |
| Contra-Indications | Combination with zalcitabine; for patients weighing less than 40kg the fixed combination with abacavir and AZT is avoided and instead each drug is used separately. |
| Side Effects | Peripheral neuropathy, rashes, diarrhoea; fatigue; anaemia; neutropenia; thrombocytopenia; fever; rash; raised liver enzymes. |
| Dosage | Children above 12yrs and adults; 150mg BD or 300mg OD. For children 0.25-12yrs; 4mg/kg BD (max.300mg daily). (the drug is taken on an empty stomach). HBV: Children above 12yrs and adults; 100mg OD. For children 2-11yrs; 3mg/kg OD (max. 100mg daily). HIV/HBV co-infection: 150mg BD. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |
Combinations ;
| 1. Lamivudine / Tenofovir | |
|---|---|
| Drug Indication | HIV infection |
| Precautions | see under lamivudine and tenofovir |
| Contra-Indications | see under lamivudine and tenofovir |
| Side Effects | see under lamivudine and tenofovir |
| Dosage | 1 tablet once daily |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Telavir | Cosmos Limited. | Cosmos Limited | 300mg/300mg | 30 | Tablet | per tablet | KES 1,500.00 |
| Telavir | Cipla Ltd. | Surgipharm Ltd | 300mg/300mg | 30 | Tablet | per tablet | KES 1,200.00 |
| 2. Lamivudine / Tenofovir / Efavirenz | |
|---|---|
| Drug Indication | HIV infection |
| Precautions | see under lamivudine , tenofovir and Efavirenz |
| Contra-Indications | see under lamivudine , tenofovir and Efavirenz |
| Side Effects | see under lamivudine , tenofovir and Efavirenz |
| Dosage | 1 tablet once daily |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Telavir-EF | Cosmos Limited. | Cosmos Limited | 300mg/300mg/600mg | 30 | Tablet | per tablet | KES 2,400.00 |
| 3. Lamivudine / Zidovudine | |
|---|---|
| Drug Indication | HIV infection |
| Precautions | see under lamivudine and zidovudine |
| Contra-Indications | see under lamivudine and zidovudine |
| Side Effects | see under lamivudine and zidovudine |
| Dosage | 1 tab BD |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Combivir | GlaxoSmithkline | GlaxoSmithKline | 150mg/300mg | 60 | Tablet | per tablet | KES 5,499.90 |
| Duovir | Cipla Ltd. | Surgipharm Ltd | 150mg/300mg | 60 | Tablet | per tablet | KES 1,311.00 Nett |
| Lazid | Emcure Pharmaceuticals Limited | Saicare Enterprises Ltd. | 150mg/300mg | 60 | Tablet | per tablet | KES 2,200.00 |
| Lazidariv | Cosmos Limited. | Cosmos Limited | 150mg/300mg | 60 | Tablet | per tablet | KES 1,200.00 |
| Zidolam | Hetero Drugs Ltd | Unisel Pharma (K) Ltd. | 150mg/300mg | 60 | Tablet | per tablet | KES 1,420.00 |
| 4. Lamivudine / Zidovudine / Abacavir | |
|---|---|
| Drug Indication | HIV infection |
| Precautions | see under lamivudine, abacavir and zidovudine |
| Contra-Indications | see under lamivudine, abacavir and zidovudine |
| Side Effects | see under lamivudine, abacavir and zidovudine |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |
| 5. Lamivudine / Zidovudine / Nevirapine | |
|---|---|
| Drug Indication | HIV infection |
| Precautions | see under lamivudine, nevirapine and zidovudine |
| Contra-Indications | see under lamivudine, nevirapine and zidovudine |
| Side Effects | see under lamivudine, nevirapine and zidovudine |
| Special Information | It is the unmodified Beta-L enantiomer of naturally-occurring thymidine. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Duovir-N | Cipla Ltd. | Surgipharm Ltd | 150mg/300mg/200mg | 30 | Capsule | per capsule | KES 1,245.00 |
| Duovir-N | Cipla Ltd. | Surgipharm Ltd | 150mg/300mg/200mg | 60 | Capsule | per capsule | KES 1,600.00 |
| Lazidariv-N | Cosmos Limited. | Cosmos Limited | 150mg/300mg/200mg | 60 | Tablet | per tablet | KES 1,500.00 |